Korean Genome Project: 1094 Korean personal genomes with clinical information.
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ABSTRACT:
SUBMITTER: Jeon S
PROVIDER: S-EPMC7385432 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Korean Genome Project: 1094 Korean personal genomes with clinical information.
Jeon Sungwon S Bhak Youngjune Y Choi Yeonsong Y Jeon Yeonsu Y Kim Seunghoon S Jang Jaeyoung J Jang Jinho J Blazyte Asta A Kim Changjae C Kim Yeonkyung Y Shim Jungae J Kim Nayeong N Kim Yeo Jin YJ Park Seung Gu SG Kim Jungeun J Cho Yun Sung YS Park Yeshin Y Kim Hak-Min HM Kim Byoung-Chul BC Park Neung-Hwa NH Shin Eun-Seok ES Kim Byung Chul BC Bolser Dan D Manica Andrea A Edwards Jeremy S JS Church George G Church George G Lee Semin S Bhak Jong J
Science advances 20200527 22
We present the initial phase of the Korean Genome Project (Korea1K), including 1094 whole genomes (sequenced at an average depth of 31×), along with data of 79 quantitative clinical traits. We identified 39 million single-nucleotide variants and indels of which half were singleton or doubleton and detected Korean-specific patterns based on several types of genomic variations. A genome-wide association study illustrated the power of whole-genome sequences for analyzing clinical traits, identifyin ...[more]
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