Volitional social interaction prevents drug addiction in rat models.
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ABSTRACT:
SUBMITTER: Venniro M
PROVIDER: S-EPMC7386559 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Volitional social interaction prevents drug addiction in rat models.
Venniro Marco M Zhang Michelle M Caprioli Daniele D Hoots Jennifer K JK Golden Sam A SA Heins Conor C Morales Marisela M Epstein David H DH Shaham Yavin Y
Nature neuroscience 20181015 11
Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and ...[more]
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