Unknown

Dataset Information

0

Efficacy and safety of dapagliflozin plus saxagliptin vs monotherapy as added to metformin in patients with type 2 diabetes: A meta-analysis.


ABSTRACT: BACKGROUND:This study aim at evaluating the efficacy and safety of dapagliflozin plus saxagliptin vs monotherapy as added to metformin in patients with type 2 diabetes mellitus (T2DM). METHOD:PubMed, Cochrane library, Embase, CNKI and Wanfang databases were searched up to 31 December 2019. Randomized controlled trials (RCTs) applicable in dapagliflozin plus saxagliptin vs monotherapy as added to metformin in the treatment of T2DM were included. The outcomes included changes in HbA1c, FPG, body weight, SBP, DBP and adverse reactions. Fixed or random effects model were used to assess these outcomes. RESULTS:In this study, 8 RCTs involved 7346 patients were included. Compared with dapagliflozin plus metformin(DM) group, patients treated with dapagliflozin plus saxagliptin add on to metformin(DSM) could significantly increase the adjusted mean change levels of HbA1c, FPG, SBP and DBP(P?

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC7386974 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Efficacy and safety of dapagliflozin plus saxagliptin vs monotherapy as added to metformin in patients with type 2 diabetes: A meta-analysis.

Zhuang Yan Y   Song Jin J   Ying Miaofa M   Li Mingxing M  

Medicine 20200701 30


<h4>Background</h4>This study aim at evaluating the efficacy and safety of dapagliflozin plus saxagliptin vs monotherapy as added to metformin in patients with type 2 diabetes mellitus (T2DM).<h4>Method</h4>PubMed, Cochrane library, Embase, CNKI and Wanfang databases were searched up to 31 December 2019. Randomized controlled trials (RCTs) applicable in dapagliflozin plus saxagliptin vs monotherapy as added to metformin in the treatment of T2DM were included. The outcomes included changes in HbA  ...[more]

Similar Datasets

| S-EPMC6220756 | biostudies-literature
| S-EPMC6667916 | biostudies-literature
| S-EPMC6771748 | biostudies-literature
| S-EPMC2732156 | biostudies-literature
| S-EPMC3946011 | biostudies-literature
| S-EPMC7318158 | biostudies-literature
| S-EPMC5969323 | biostudies-literature
| S-EPMC4412636 | biostudies-literature
| S-EPMC6150435 | biostudies-literature
| S-EPMC5969082 | biostudies-literature