Immunoglobulin G and immunoglobulin G subclass concentrations differ according to sex and race.

ABSTRACT:

Background

Serum immunoglobulin G (IgG) concentrations are integral to the workup of immune deficiencies and IgG4-related disease (IgG4-RD). Demographic differences in IgG concentrations are poorly described but can influence test interpretation, contribute to racial disparities in primary immunodeficiency diagnosis, and explain demographic differences in IgG concentrations in IgG4-RD.

Objective

To assess differences in IgG and IgG subclass concentrations according to sex and race.

Methods

We identified patients with IgG and IgG subclass concentrations measured in a large health care system. Multivariate-adjusted differences in IgG and IgG subclass concentrations and the proportion of subjects with results outside of reference ranges according to sex and race were est

SUBMITTER: Harkness T 

PROVIDER: S-EPMC7387162 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature