Dataset Information

Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age.

ABSTRACT: BACKGROUND:Obesity is a malnourishment epidemic worldwide. A meta-analysis of prospective human studies across the world demonstrated a consistent positive association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) and children with obesity. The present study evaluates the association of maternal exposure to DDT and DDE with the risk of obesity in daughters during their mid-life in a prospective birth cohort with up to 53 years of follow-up. METHODS:Gravidas' blood was collected during their 1959-1967 enrollment into the prospective Child Health and Development Studies birth cohort in California. Their daughters aged 44-53 years had their height, weight, and waist circumference measured during a home visit to evaluate associations of daughters' adiposity and relative risk of overweight and obesity with their mothers' prenatal serum levels of DDT and DDE quantified by gas chromatograph-tandem mass spectrometer (n?=?511). RESULTS:Maternal o,p'-DDT was positively associated with body mass index (??=?0.59?kg/m2 per ln ng/ml (95th percentile confidence interval, 95% CI: 0.17, 1.00)) and waist circumference (??=?1.19?cm per ln ng/ml (95% CI: 0.26, 2.13)) in multivariable models. Maternal o,p'-DDT was positively associated with a 26% (95% CI: 6-49) to 31% (95% CI: 6-62) higher risk of overweight and the same magnitude of additional risk for obesity, based on waist circumference and BMI definitions respectively, in multivariable models. CONCLUSIONS:These data indicate maternal DDT exposure is significantly associated with increased obesity risk among middle-aged women independent of the obesity definition, confounding, and obesity risk factors. Our findings suggest that policies supporting the use of DDT for malaria vector abatement need to consider the obesity risk as a health cost when weighing the benefits of using DDT in malaria vector control.

SUBMITTER: La Merrill MA

PROVIDER: S-EPMC7387196 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age.

La Merrill Michele A MA Krigbaum Nickilou Y NY Cirillo Piera M PM Cohn Barbara A BA

International journal of obesity (2005) 20200515 8

<h4>Background</h4>Obesity is a malnourishment epidemic worldwide. A meta-analysis of prospective human studies across the world demonstrated a consistent positive association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) and children with obesity. The present study evaluates the association of maternal exposure to DDT and DDE with the risk of obesity in daughters during their mid-life in a prospective b ...[more]

PMID: 32415255

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Project description:BackgroundFluted pumpkin (Telfairia occidentalis) and amaranth (Amaranthus spp.) are common leafy vegetables produced and consumed in southwestern Nigeria. These vegetables attract insect pests which are controlled by pesticides that may have adverse impacts on human health.ObjectivesTo determine the levels of dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH) pesticide residues in the two vegetables and evaluate the potential health risks associated with their consumption.MethodsThe pesticide residue levels were quantitatively and qualitatively determined using a gas chromatograph coupled with electron capture detector. Health risk assessment were performed using estimated average daily intake and hazard indices for two weight categories: children (16.7 kg) and adults (60 kg).ResultsThe results showed that delta-HCH, DDT and methoxychlor were predominantly detected in the two vegetables from both farms and markets. In amaranth, the mean concentration of methoxychlor, DDT and delta-HCH were 4.590 ± 2.774 mg/kg (dry weight (dw)), 0.757 ± 0.457 mg/kg (dw) and 0.577 ± 0.390 mg/kg (dw), respectively, while fluted pumpkin levels were 6.223 ± 2.489 mg/kg dw (methoxychlor), 0.504 ± 0.056 mg/kg dw (delta-HCH) and 0.486 ± 0.123 mg/kg dw (DDT). The levels of HCH and DDT residues were generally above the United Kingdom/European Commission maximum residue limit. The analysis of health risk estimates for non-carcinogenic risk revealed that for both vegetables, the hazard quotient for p, p' DDT and methoxychlor was >1 for both children and adults. The health risk estimates for carcinogenic risk revealed that hazard indices values were >1 for children for both vegetables and alpha-HCH had a hazard index >1 for adults for amaranth. This means the residue exceeds acceptable standard and present potential risk to consumers of these vegetables.ConclusionsThe results obtained from the present study indicate that consumption of amaranth contaminated with alpha-HCH could pose a carcinogenic risk for adult consumers. The consumption of the two vegetables could pose both non-carcinogenic and carcinogenic health risks to children and adults. Therefore, there is need for strict enforcement of regulations on pesticide usage to minimize human health risks.Competing interestsThe authors declare no competing financial interests.

Project description:ImportanceThe first pediatric lead screening typically occurs at 1-year well-child care visits. However, data on the extent of maternal lead exposure and its long-term consequences for child health are lacking.ObjectiveTo investigate the associations between maternal red blood cell (RBC) lead levels and intergenerational risk of overweight or obesity (OWO) and whether adequate maternal folate status is associated with a reduction in OWO risk.Design, setting, and participantsProspective birth cohort study. The analysis was conducted from July 14, 2018, to August 2, 2019, at Johns Hopkins Bloomberg School of Public Health. This study included 1442 mother-child pairs recruited at birth from October 27, 2002, to October 10, 2013, and followed up prospectively at Boston Medical Center.Main outcomes and measuresChild body mass index (BMI) z score, calculated according to US national reference data, and OWO, defined as BMI at or exceeding the 85th percentile for age and sex. Maternal RBC lead levels and plasma folate levels were measured in samples obtained 24 to 72 hours after delivery; child whole-blood lead level was obtained from the first pediatric lead screening.ResultsThe mean (SD) age of mothers and children was 28.6 (6.5) years and 8.1 (3.1) years, respectively; 50.1% of children were boys. The median maternal RBC lead level and plasma folate level were 2.5 (interquartile range [IQR], 1.7-3.8) μg/dL and 32.2 (IQR, 22.1-44.4) nmol/L, respectively. The median child whole-blood lead level and child BMI z score were 1.4 (IQR, 1.4-2.0) μg/dL and 0.78 (IQR, -0.08 to 1.71), respectively. Maternal RBC lead level was associated with child OWO risk in a dose-response fashion, with an odds ratio (OR) of 1.65 (95% CI, 1.18-2.32) for high maternal RBC lead level (≥5.0 μg/dL) compared with low maternal RBC lead level (<2.0 μg/dL). Child OWO was highest among children of OWO mothers with high RBC lead levels (adjusted OR, 4.24; 95% CI, 2.64-6.82) compared with children of non-OWO mothers with low RBC lead levels. Children of OWO mothers with high RBC lead levels had 41% lower OWO risk (OR, 0.59; 95% CI, 0.36-0.95; P = .03) if their mothers had adequate plasma folate levels (≥20.4 nmol/L) compared with their counterparts.Conclusions and relevanceIn this sample of a US urban population, findings suggest that maternal elevated lead exposure was associated with increased risk of intergenerational OWO independent of postnatal blood lead levels. Adequate maternal folate status appeared to be associated with lower OWO risk. If confirmed by additional studies, these findings have implications for prenatal lead screening and management to minimize adverse health consequences on children.

Dataset Information

Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age.

Publications

Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age.

Similar Datasets

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