Association of Opioids and Nonsteroidal Anti-inflammatory Drugs With Outcomes in CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study.

ABSTRACT:

Rationale & objective

Safe analgesic choices are limited in chronic kidney disease (CKD). We conducted a comparative analysis of harm from opioids versus nonsteroidal anti-inflammatory drugs (NSAIDs) in CKD.

Study design

Prospective cohort study.

Setting & participants

3,939 patients with CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Exposures

30-day analgesic use reported at annual visits.

Outcomes

A composite outcome of 50% glomerular filtration rate reduction and kidney failure requiring kidney replacement therapy (KRT), as well as the outcomes of kidney failure requiring KRT, hospitalization, and pre-kidney failure death.

Analytical approach

Marginal structural models with time-updated exposures.

Results

Participants were

SUBMITTER: Zhan M 

PROVIDER: S-EPMC7387229 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature