Ontology highlight
ABSTRACT:
SUBMITTER: Verma S
PROVIDER: S-EPMC7387335 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Communications biology 20200728 1
Diethylcarbamazine is an important classic drug used for prevention and treatment of lymphatic filariasis and loiasis, diseases caused by filarial nematodes. Despite many studies, its site of action has not been established. Until now, the consensus has been that diethylcarbamazine works by activating host immune systems, not by a direct action on the parasites. Here we show that low concentrations of diethylcarbamazine have direct and rapid (<30 s) temporary spastic paralyzing effects on the pa ...[more]