Ontology highlight
ABSTRACT:
SUBMITTER: Tift MS
PROVIDER: S-EPMC7387684 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in physiology 20200722
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human pop ...[more]