Ontology highlight
ABSTRACT:
SUBMITTER: Dold M
PROVIDER: S-EPMC7387762 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Dold Markus M Bartova Lucie L Kasper Siegfried S
The international journal of neuropsychopharmacology 20200701 7
In this meta-analysis, we aimed to estimate and compare the efficacy of add-on treatment of antidepressants with esketamine nasal spray and second-generation antipsychotics in patients with nonpsychotic major depressive disorder and inadequate response to antidepressants. Searching for acute-phase, double-blind, placebo-controlled, randomized trials, we found 22 second-generation antipsychotic (n = 8363) and 3 intranasal esketamine (n = 641) studies. Mean change in the Montgomery Åsberg Depressi ...[more]