Ontology highlight
ABSTRACT:
SUBMITTER: Ji LS
PROVIDER: S-EPMC7387970 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ji Long-Shan LS Sun Xue-Hua XH Zhang Xin X Zhou Zhen-Hua ZH Yu Zhuo Z Zhu Xiao-Jun XJ Huang Ling-Ying LY Fang Miao M Gao Ya-Ting YT Li Man M Gao Yue-Qiu YQ
Journal of immunology research 20200720
Helping B cells and antibody responses is a major function of CD4<sup>+</sup>T helper cells. Follicular helper T (Tfh) cells are identified as a subset of CD4<sup>+</sup>T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of CXCR5, PD-1, IL-21, and other characteristic markers. Accumulating evidence has demonstrated that the dysregulation of Tfh cells is involved in infectious, inflammatory, and autoimmune diseases, including lym ...[more]