Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial.

ABSTRACT:

Importance

Opioid-induced ventilatory depression and hypoxemia is common, severe, and often unrecognized in postoperative patients. To the extent that nonopioid analgesics reduce opioid consumption, they may decrease postoperative hypoxemia.

Objective

To test the hypothesis that duration of hypoxemia is less in patients given intravenous acetaminophen than those given placebo.

Design, setting, and participants

Randomized, placebo-controlled, double-blind trial conducted at 2 US academic hospitals among 570 patients who were undergoing abdominal surgery, enrolled from February 2015 through October 2018 and followed up until February 2019.

Interventions

Participants were randomized to receive either intravenous acetaminophen, 1 g (n = 289), or normal saline place

SUBMITTER: Turan A 

PROVIDER: S-EPMC7388016 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature