Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC7388591 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200501 6493
Synaptic vesicles accumulate neurotransmitters, enabling the quantal release by exocytosis that underlies synaptic transmission. Specific neurotransmitter transporters are responsible for this activity and therefore are essential for brain function. The vesicular glutamate transporters (VGLUTs) concentrate the principal excitatory neurotransmitter glutamate into synaptic vesicles, driven by membrane potential. However, the mechanism by which they do so remains poorly understood owing to a lack o ...[more]