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The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study.


ABSTRACT: Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on mood is underrecognized and the literature is conflicting. Therefore, using a very large and well-characterised sample of older adults with hypertension, we aimed to investigate the prevalence of depressive symptoms in users of different antihypertensive classes. We analysed baseline data from 14,195 older individuals with hypertension enroled in a large clinical trial. Median age was 75 years. The association of antihypertensive use by class and depression prevalence, as measured by a validated depression scale, was determined using logistic regression models. Multivariable logistic models were implemented to account for important confounding factors. Our analyses showed a positive association between depressive symptoms and the use of beta blockers (BB) (OR: 1.37; 95% CI: 1.17-1.60, p?

SUBMITTER: Agustini B 

PROVIDER: S-EPMC7390661 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study.

Agustini Bruno B   Mohebbi Mohammadreza M   Woods Robyn L RL   McNeil John J JJ   Nelson Mark R MR   Shah Raj C RC   Murray Anne M AM   Ernst Michael E ME   Reid Christopher M CM   Tonkin Andrew A   Lockery Jessica E JE   Berk Michael M  

Journal of human hypertension 20200130 11


Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on mood is underrecognized and the literature is conflicting. Therefore, using a very large and well-characterised sample of older adults with hypertension, we aimed to investigate the prevalence of depressive symptoms in users of different antihypertensive classes. We analysed baseline data from 14,195 older individuals with hypertension enroled in a large clinical tria  ...[more]

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