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Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis.

ABSTRACT: Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The E? enhancer located upstream of the C? gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the C? gene controls late events in B-cell maturation such as IgH transcription, somatic hypermutation, and class switch recombination. Convincing demonstrations of the essential contributions of both E? and 3'RR in B-cell lymphomagenesis have been provided by transgenic and knock-in animal models which bring the oncogene c-myc under E?/3'RR transcriptional control. This short review summarizes the different mouse models so far available and their interests/limitations for progress in our understanding of human c-myc-induced B-cell lymphomagenesis.

SUBMITTER: Ferrad M 

PROVIDER: S-EPMC7390917 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Mouse Models of <i>c-myc</i> Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis.

Ferrad Melissa M   Ghazzaui Nour N   Issaoui Hussein H   Cook-Moreau Jeanne J   Denizot Yves Y  

Frontiers in immunology 20200723

Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The E<sub>μ</sub> enhancer located upstream of the C<sub>μ</sub> gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the C<sub>α</sub> gene controls late events in B-ce  ...[more]

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