Ontology highlight
ABSTRACT:
SUBMITTER: Ferrad M
PROVIDER: S-EPMC7390917 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200723
Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The E<sub>μ</sub> enhancer located upstream of the C<sub>μ</sub> gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the C<sub>α</sub> gene controls late events in B-ce ...[more]