Ontology highlight
ABSTRACT:
SUBMITTER: Symonds AL
PROVIDER: S-EPMC7391068 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Symonds Alistair Lj AL Zheng Wei W Miao Tizong T Wang Haiyu H Wang TieShang T Kiome Ruth R Hou Xiujuan X Li Suling S Wang Ping P
Life science alliance 20200724 9
The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now found that the Egr2<sup>+</sup> subset (PD-1<sup>high</sup> MP) of MP CD4 T cells expresses high levels of checkpoint molecules (PD-1 and Lag3) and also markers of effector T cells (CXCR3 and ICAM-1). Egr2/3 are not required for PD-1<sup>high</sup> MP CD4 cell development but mediate a unique transcriptiona ...[more]