Ontology highlight
ABSTRACT:
SUBMITTER: Ke J
PROVIDER: S-EPMC7391411 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ke Juntao J Zhu Ying Y Miao Xiaoping X
Pediatric investigation 20180901 3
Hirschsprung's disease (HSCR) is a rare and complex congenital disorder characterized by the absence of the enteric neurons in lower digestive tract with an incidence of 1/5 000. Affected infant usually suffer from severe constipation with megacolon and distended abdomen, and face long-term complications even after surgery. In the last 2 decades, great efforts and progresses have been made in understanding the genetics and molecular biological mechanisms that underlie HSCR. However, only a small ...[more]