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Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence.


ABSTRACT: Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strategies. In gynecologic malignancies, potential therapeutic targeted agents include antiangiogenic agents, poly (ADP-ribose) polymerase (PARP) inhibitors, tumor-intrinsic signaling pathway inhibitors, selective estrogen receptor downregulators, and immune checkpoint inhibitors. In this article, we provide a comprehensive review of the clinical evidence of targeted agents in gynecological cancers and discuss the future implication.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7391668 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence.

Wang Qiao Q   Peng Hongling H   Qi Xiaorong X   Wu Min M   Zhao Xia X  

Signal transduction and targeted therapy 20200729 1


Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strategies. In gynecologic malignancies, potential therapeutic targeted agents include antiangiogenic agents, poly (ADP-ribose) polymerase (PARP) inhibitors, tumor-intrinsic signaling pathway inhibitors, s  ...[more]

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