Association between inflammatory bowel disease and bullous pemphigoid: a population-based case-control study.

ABSTRACT: The coexistence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) has been reported. No large-scale study to date has explored the relationship between these diseases. This population-based case-control study examined the association between IBD and BP by using a nationwide database. A total of 5,263 BP patients and 21,052 age- and gender-, hospital visit number-matched controls were identified in the National Health Insurance Research Database of Taiwan (1997-2013). Demographic characteristics and comorbidities including IBD were compared. Logistic regression was conducted to examine the predicting factors for BP. The mean age at diagnosis was 74.88 years and 54.3% of subjects were male. BP patients tended to have more cardiovascular risk factors, autoimmune and neurologic comorbidities, and hematologic cancers than matched controls. There were 20 cases of IBD (0.38%), mostly ulcerative colitis (N?=?17, 0.32%) among BP patients, compared to 33 IBD cases (0.16%) among controls (p?

SUBMITTER: Chen YJ 

PROVIDER: S-EPMC7391771 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature