Ontology highlight
ABSTRACT:
SUBMITTER: Laczko D
PROVIDER: S-EPMC7392193 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Laczkó Dorottya D Hogan Michael J MJ Toulmin Sushila A SA Hicks Philip P Lederer Katlyn K Gaudette Brian T BT Castaño Diana D Amanat Fatima F Muramatsu Hiromi H Oguin Thomas H TH Ojha Amrita A Zhang Lizhou L Mu Zekun Z Parks Robert R Manzoni Tomaz B TB Roper Brianne B Strohmeier Shirin S Tombácz István I Arwood Leslee L Nachbagauer Raffael R Karikó Katalin K Greenhouse Jack J Pessaint Laurent L Porto Maciel M Putman-Taylor Tammy T Strasbaugh Amanda A Campbell Tracey-Ann TA Lin Paulo J C PJC Tam Ying K YK Sempowski Gregory D GD Farzan Michael M Choe Hyeryun H Saunders Kevin O KO Haynes Barton F BF Andersen Hanne H Eisenlohr Laurence C LC Weissman Drew D Krammer Florian F Bates Paul P Allman David D Locci Michela M Pardi Norbert N
Immunity 20200730 4
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19, developing effective and safe vaccines is a top research priority. Here, we provide a detailed evaluation of the immunogenicity of lipid nanoparticle-encapsulated, nucleoside-modified mRNA (mRNA-LNP) vaccines encoding the full-length SARS-CoV-2 spike protein or the spike receptor binding domain in mice. We demonstr ...[more]