Ontology highlight
ABSTRACT:
SUBMITTER: Ryu SW
PROVIDER: S-EPMC7392334 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ryu Seung W SW Stewart Rose R Pectol D Chase DC Ender Nicolette A NA Wimalarathne Oshadi O Lee Ji-Hoon JH Zanini Carlos P CP Harvey Antony A Huibregtse Jon M JM Mueller Peter P Paull Tanya T TT
PLoS biology 20200720 7
The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrate quantitative identification of HSP70 and 71 kDa heat shock cognate (HSC70) clients using a ubiquitin-mediated proximity tagging strategy and show that, despite their high degree o ...[more]