Ontology highlight
ABSTRACT:
SUBMITTER: Lei X
PROVIDER: S-EPMC7392898 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lei Xiaobo X Dong Xiaojing X Ma Ruiyi R Wang Wenjing W Xiao Xia X Tian Zhongqin Z Wang Conghui C Wang Ying Y Li Li L Ren Lili L Guo Fei F Zhao Zhendong Z Zhou Zhuo Z Xiang Zichun Z Wang Jianwei J
Nature communications 20200730 1
The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood. Here we show that SARS-CoV-2 induces overt but delayed type-I interferon (IFN) responses. By screening 23 viral proteins, we find that SARS-CoV-2 NSP1, NSP3, NSP12, NSP13, NSP14, ORF3, ORF6 and M protein inhibit Sendai virus-induced IFN-β promoter activation, whereas NSP2 and S protein exert o ...[more]