Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC7393072 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yang Chunbo C Eleftheriadou Magdalini M Kelaini Sophia S Morrison Thomas T González Marta Vilà MV Caines Rachel R Edwards Nicola N Yacoub Andrew A Edgar Kevin K Moez Arya A Ivetic Aleksandar A Zampetaki Anna A Zeng Lingfang L Wilkinson Fiona L FL Lois Noemi N Stitt Alan W AW Grieve David J DJ Margariti Andriana A
Nature communications 20200730 1
Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patients. QKI-7 is also highly expressed in human coronary arterial ECs from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation. QKI-7 expression is tightly controlled by RNA splicing fact ...[more]