Ontology highlight
ABSTRACT:
SUBMITTER: Riberdy JM
PROVIDER: S-EPMC7393323 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Riberdy Janice M JM Zhou Sheng S Zheng Fei F Kim Young-In YI Moore Jennifer J Vaidya Abishek A Throm Robert E RE Sykes April A Sahr Natasha N Bonifant Challice L CL Ryu Byoung B Gottschalk Stephen S Velasquez Mireya Paulina MP
Molecular therapy. Methods & clinical development 20200630
Chimeric antigen receptor (CAR) T cells targeting CD123, an acute myeloid leukemia (AML) antigen, hold the promise of improving outcomes for patients with refractory/recurrent disease. We generated five lentiviral vectors encoding CD20, which may serve as a target for CAR T cell depletion, and 2<sup>nd</sup> or 3<sup>rd</sup> generation CD123-CARs since the benefit of two costimulatory domains is model dependent. Four CARs were based on the CD123-specific single-chain variable fragment (scFv) 26 ...[more]