Unknown

Dataset Information

0

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.

ABSTRACT: The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with control patients. In human valve interstitials cells submitted to a pro-osteogenic medium, PCSK9 levels increased and a PCSK9 neutralizing antibody significantly reduced calcium accumulation.

SUBMITTER: Perrot N 

PROVIDER: S-EPMC7393433 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the <i>PCSK9</i> R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with co  ...[more]

Similar Datasets

Genomics GWAS on Calcific Aortic Valve Stenosis
| PRJNA420787 | ENA
Genomics GWAS on Calcific Aortic Valve Stenosis
| PRJNA420788 | ENA
Unknown Calcific aortic valve stenosis: methods, models, and mechanisms.
| S-EPMC3150727 | biostudies-literature
Unknown Role for Galectin-3 in Calcific Aortic Valve Stenosis.
| S-EPMC5210369 | biostudies-literature
Unknown Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
| S-EPMC6547086 | biostudies-literature
Unknown Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis.
| S-EPMC4956483 | biostudies-literature
Unknown Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis.
| S-EPMC3180988 | biostudies-literature
Unknown Calcific aortic stenosis.
| S-EPMC5127286 | biostudies-literature
Metabolomics Metabolomics Characterization of Human Calcific Aortic Valve Stenosis
2020-02-03 | MTBLS1267 | MetaboLights
Unknown Cardiac Autonomic Response to Active Standing in Calcific Aortic Valve Stenosis.
| S-EPMC8124878 | biostudies-literature