Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.
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ABSTRACT:
SUBMITTER: Perrot N
PROVIDER: S-EPMC7393433 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic and In Vitro Inhibition of <i>PCSK9</i> and Calcific Aortic Valve Stenosis.
Perrot Nicolas N Valerio Vincenza V Moschetta Donato D Boekholdt S Matthijs SM Dina Christian C Chen Hao Yu HY Abner Erik E Martinsson Andreas A Manikpurage Hasanga D HD Rigade Sidwell S Capoulade Romain R Mass Elvira E Clavel Marie-Annick MA Le Tourneau Thierry T Messika-Zeitoun David D Wareham Nicholas J NJ Engert James C JC Polvani Gianluca G Pibarot Philippe P Esko Tõnu T Smith J Gustav JG Mathieu Patrick P Thanassoulis George G Schott Jean-Jacques JJ Bossé Yohan Y Camera Marina M Thériault Sébastien S Poggio Paolo P Arsenault Benoit J BJ
JACC. Basic to translational science 20200701 7
The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the <i>PCSK9</i> R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with co ...[more]
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