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A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.

ABSTRACT: BACKGROUND:Prediction of brain invasion pre-operatively rather than postoperatively would contribute to the selection of surgical techniques, predicting meningioma grading and prognosis. Here, we aimed to predict the risk of brain invasion in meningioma pre-operatively using a nomogram by incorporating radiomic and clinical features. METHODS:In this case-control study, 1728 patients from Beijing Tiantan Hospital (training cohort: n = 1070) and Lanzhou University Second Hospital (external validation cohort: n = 658) were diagnosed with meningiomas by histopathology. Radiomic features were extracted from the T1-weighted post-contrast and T2-weighted magnetic resonance imaging. The least absolute shrinkage and selection operator was used to select the most informative features of different modalities. The support vector machine algorithm was used to predict the risk of brain invasion. Furthermore, a nomogram was constructed by incorporating radiomics signature and clinical risk factors, and decision curve analysis was used to validate the clinical usefulness of the nomogram. FINDINGS:Sixteen features were significantly correlated with brain invasion. The clinicoradiomic model derived from the fusing MRI sequences and sex resulted in the best discrimination ability for risk prediction of brain invasion, with areas under the curves (AUCs) of 0•857 (95% CI, 0•831-0•887) and 0•819 (95% CI, 0•775-0•863) and sensitivities of 72•8% and 90•1% in the training and validation cohorts, respectively. INTERPRETATION:Our clinicoradiomic model showed good performance and high sensitivity for risk prediction of brain invasion in meningioma, and can be applied in patients with meningiomas. FUNDING:This work was supported by the National Natural Science Foundation of China (81772006, 81922040); the Youth Innovation Promotion Association CAS (grant numbers 2019136); special fund project for doctoral training program of Lanzhou University Second Hospital (grant numbers YJS-BD-33).

SUBMITTER: Zhang J

PROVIDER: S-EPMC7393568 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.

Zhang Jing J Yao Kuan K Liu Panpan P Liu Zhenyu Z Han Tao T Zhao Zhiyong Z Cao Yuntai Y Zhang Guojin G Zhang Junting J Tian Jie J Zhou Junlin J

EBioMedicine 20200730

<h4>Background</h4>Prediction of brain invasion pre-operatively rather than postoperatively would contribute to the selection of surgical techniques, predicting meningioma grading and prognosis. Here, we aimed to predict the risk of brain invasion in meningioma pre-operatively using a nomogram by incorporating radiomic and clinical features.<h4>Methods</h4>In this case-control study, 1728 patients from Beijing Tiantan Hospital (training cohort: n = 1070) and Lanzhou University Second Hospital (e ...[more]

PMID: 32739863

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Project description:BackgroundRadiomics has emerged as a new approach that can help identify imaging information associated with tumor pathophysiology. We developed and validated a radiomics nomogram for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC).MethodsTwo hundred and eight patients with pathologically confirmed HCC (training cohort: n = 146; validation cohort: n = 62) who underwent preoperative gadoxetic acid-enhanced magnetic resonance (MR) imaging were included. Least absolute shrinkage and selection operator logistic regression was applied to select features and construct signatures derived from MR images. Univariate and multivariate analyses were used to identify the significant clinicoradiological variables and radiomics signatures associated with MVI, which were then incorporated into the predictive nomogram. The performance of the radiomics nomogram was evaluated by its calibration, discrimination, and clinical utility.ResultsHigher α-fetoprotein level (p = 0.046), nonsmooth tumor margin (p = 0.003), arterial peritumoral enhancement (p < 0.001), and the radiomics signatures of hepatobiliary phase (HBP) T1-weighted images (p < 0.001) and HBP T1 maps (p < 0.001) were independent risk factors of MVI. The predictive model that incorporated the clinicoradiological factors and the radiomic features derived from HBP images outperformed the combination of clinicoradiological factors in the training cohort (area under the curves [AUCs] 0.943 vs. 0.850; p = 0.002), though the validation did not have a statistical significance (AUCs 0.861 vs. 0.759; p = 0.111). The nomogram based on the model exhibited C-index of 0.936 (95% CI 0.895-0.976) and 0.864 (95% CI 0.761-0.967) in the training and validation cohort, fitting well in calibration curves (p > 0.05). Decision curve analysis further confirmed the clinical usefulness of the nomogram.ConclusionsThe nomogram incorporating clinicoradiological risk factors and radiomic features derived from HBP images achieved satisfactory preoperative prediction of the individualized risk of MVI in patients with HCC.

Dataset Information

A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.

Publications

A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.

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