Ontology highlight
ABSTRACT:
SUBMITTER: Sladek AL
PROVIDER: S-EPMC7393603 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in synaptic neuroscience 20200724
AMPA-type glutamate receptors in the CNS are normally impermeable to Ca<sup>2+</sup>, but the aberrant expression of Ca<sup>2+</sup>-permeable AMPA receptors (CP-AMPARs) occurs in pathological conditions such as ischemia or epilepsy, or degenerative diseases such as ALS. Here, we show that select populations of retinal ganglion cells (RGCs) similarly express high levels of CP-AMPARs in a mouse model of glaucoma. CP-AMPAR expression increased dramatically in both On sustained alpha and Off transi ...[more]