Genetic and behavioral modification of hemoglobin and iron status among first-time and high-intensity blood donors.

ABSTRACT:

Background

Some people rapidly develop iron deficiency anemia following blood donation, while others can repeatedly donate without becoming anemic.

Methods

Two cohorts of blood donors were studied. Participants (775) selected from a 2-year longitudinal study were classified into six analysis groups based on sex, donation intensity, and low hemoglobin deferral. Associations with iron supplement use, cigarette smoking, and four genetic variants of iron metabolism were examined at enrollment and with longitudinal regression models. An unbiased assessment of genetic variability and ability to repeatedly donate blood without experiencing low hemoglobin deferral was conducted on participants (13,403) in a cross-sectional study who were examined by genome wide association (GWA).

SUBMITTER: Mast AE 

PROVIDER: S-EPMC7393610 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature