Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.

ABSTRACT: BACKGROUND:Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown. METHODS:The methylation of WT1 and CA10 was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) in a case-control study with female subjects (N?=?959). Logistic regression was used to analyze the associations, and propensity score (PS) method was used to adjust confounders. RESULTS:The results showed that WT1 hypermethylation was associated with an increased risk of breast cancer, with an odds ratio (OR) of 3.07 [95% confidence interval (CI): 1.67-5.64, P?

SUBMITTER: Ge A 

PROVIDER: S-EPMC7393705 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature