Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC7393805 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wu Chuanfeng C Espinoza Diego A DA Koelle Samson J SJ Yang Di D Truitt Lauren L Schlums Heinrich H Lafont Bernard A BA Davidson-Moncada Jan K JK Lu Rong R Kaur Amitinder A Hammer Quirin Q Li Brian B Panch Sandhya S Allan David A DA Donahue Robert E RE Childs Richard W RW Romagnani Chiara C Bryceson Yenan T YT Dunbar Cynthia E CE
Science immunology 20181101 29
Natural killer (NK) cells recognize and eliminate infected and malignant cells. Their life histories are poorly understood, particularly in humans, due to lack of informative models and endogenous clonal markers. Here, we apply transplantation of barcoded rhesus macaque hematopoietic cells to interrogate the landscape of NK cell production, expansion, and life histories at a clonal level long term and after proliferative challenge. We identify oligoclonal populations of rhesus CD56<sup>-</sup>CD ...[more]