Ontology highlight
ABSTRACT:
SUBMITTER: Lin Q
PROVIDER: S-EPMC7394281 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Lin Qing Q Yang Xiao Ping XP Fang Dan D Ren Xiangrong X Zhou Hongyan H Fang Jiazhu J Liu Xialin X Zhou Shiyou S Wen Feng F Yao Xiaohong X Wang Ji Ming JM Su Shao Bo SB
Arteriosclerosis, thrombosis, and vascular biology 20110303 5
<h4>Objective</h4>Inflammation is closely linked to angiogenesis, and Toll-like receptors (TLRs) are the key mediators of inflammatory responses. However, the impact of TLRs on angiogenesis is incompletely understood. In this study, we determined the involvement of TLRs in angiogenesis.<h4>Methods and results</h4>In a mouse model of alkali-induced corneal neovascularization (CNV), we found that CNV was attenuated in TLR4-/- but not TLR2-/- mice. Further study revealed that the absence of TLR4 le ...[more]