Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz HR
PROVIDER: S-EPMC7394473 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Schwartz Hannah R HR Richards Ryan R Fontana Rachel E RE Joyce Anna J AJ Honeywell Megan E ME Lee Michael J MJ
Cell reports 20200601 12
When evaluating anti-cancer drugs, two different measurements are used: relative viability, which scores an amalgam of proliferative arrest and cell death, and fractional viability, which specifically scores the degree of cell killing. We quantify relationships between drug-induced growth inhibition and cell death by counting live and dead cells using quantitative microscopy. We find that most drugs affect both proliferation and death, but in different proportions and with different relative tim ...[more]