New oral spherical carbon adsorbent effectively reduces serum indoxyl sulfate levels in moderate to advanced chronic kidney disease patients: a multicenter, prospective, open-label study.
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SUBMITTER: Kim SH
PROVIDER: S-EPMC7394678 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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New oral spherical carbon adsorbent effectively reduces serum indoxyl sulfate levels in moderate to advanced chronic kidney disease patients: a multicenter, prospective, open-label study.
Kim Seok-Hyung SH Jhee Jong Hyun JH Choi Hoon Young HY Lee Sang-Ho SH Shin Sug Kyun SK Lee So-Young SY Yang Dong Ho DH Yi Joo-Hark JH Han Sang-Woong SW Jo Young-Il YI Park Hyeong Cheon HC
BMC nephrology 20200731 1
<h4>Background</h4>Elevated levels of serum indoxyl sulfate (IS) have been linked to cardiovascular complications in patients with chronic kidney disease (CKD). Oral sorbent therapy using spherical carbons selectively attenuates IS accumulation in CKD patients. This study aimed to investigate whether oral administration of a new oral spherical carbon adsorbent (OSCA), reduces serum IS levels in moderate to severe CKD patients.<h4>Methods</h4>This prospective, multicenter, open-label study enroll ...[more]
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