Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7395124 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wang Jian J Jain Abha A McDonald Leanna R LR Gambogi Craig C Lee Andrew L AL Dokholyan Nikolay V NV
Nature communications 20200731 1
Allostery in proteins influences various biological processes such as regulation of gene transcription and activities of enzymes and cell signaling. Computational approaches for analysis of allosteric coupling provide inexpensive opportunities to predict mutations and to design small-molecule agents to control protein function and cellular activity. We develop a computationally efficient network-based method, Ohm, to identify and characterize allosteric communication networks within proteins. Un ...[more]