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Role of ?V?3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target.


ABSTRACT: In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin ?V?3 plays an important role in this process. In prostate cancer, ?V?3 mediates adhesion, invasion, immune escape and neovascularization through interactions with different ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD structure could also bind to ?V?3 and cause a number of biological effects. In this article, we summarized the ligand and downstream proteins related to ?V?3-mediated prostate cancer metastasis as well as some diagnostic and therapeutic measures targeting ?V?3.

SUBMITTER: Tang L 

PROVIDER: S-EPMC7395689 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target.

Tang Lin L   Xu Meng M   Zhang Long L   Qu Lin L   Liu Xiaoyan X  

OncoTargets and therapy 20200728


In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin αVβ3 plays an important role in this process. In prostate cancer, αVβ3 mediates adhesion, invasion, immune escape and neovascularization through interactions with different ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD str  ...[more]

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