Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.
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ABSTRACT:
SUBMITTER: Hosoda Y
PROVIDER: S-EPMC7395727 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.
Hosoda Yoshikatsu Y Miyake Masahiro M Meguro Akira A Tabara Yasuharu Y Iwai Sachiko S Ueda-Arakawa Naoko N Nakano Eri E Mori Yuki Y Yoshikawa Munemitsu M Nakanishi Hideo H Khor Chiea-Chuen CC Saw Seang-Mei SM Yamada Ryo R Matsuda Fumihiko F Cheng Ching-Yu CY Mizuki Nobuhisa N Tsujikawa Akitaka A Yamashiro Kenji K
Communications biology 20200731 1
Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.32 × 10<sup>-13</sup>), and confirmed a significant association between STON2 rs2371597 and keratoconus development (P = 0.041). A ...[more]
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