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Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction.

ABSTRACT: Sex differences in 116 local gray matter volumes (GM_VOL) were assessed in 444 males and 444 females without correcting for total intracranial volume (TIV) or after adjusting the data with the scaling, proportions, power-corrected proportions (PCP), and residuals methods. The results confirmed that only the residuals and PCP methods completely eliminate TIV-variation and result in sex-differences that are "small" (?d??VOL features in predicting individuals' sex with 12 different machine learning classifiers. Sex could be reliably predicted (>?80%) when using raw local GM_VOL, but also when using scaling or proportions adjusted-data or TIV as a single predictor. Conversely, after properly controlling TIV variation with the PCP and residuals' methods, prediction accuracy dropped to [Formula: see text] 60%. It is concluded that gross morphological differences account for most of the univariate and multivariate sex differences in GM_VOL.

SUBMITTER: Sanchis-Segura C

PROVIDER: S-EPMC7395772 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction.

Sanchis-Segura Carla C Ibañez-Gual Maria Victoria MV Aguirre Naiara N Cruz-Gómez Álvaro Javier ÁJ Forn Cristina C

Scientific reports 20200731 1

Sex differences in 116 local gray matter volumes (GM<sub>VOL</sub>) were assessed in 444 males and 444 females without correcting for total intracranial volume (TIV) or after adjusting the data with the scaling, proportions, power-corrected proportions (PCP), and residuals methods. The results confirmed that only the residuals and PCP methods completely eliminate TIV-variation and result in sex-differences that are "small" (∣d∣ < 0.3). Moreover, as assessed using a totally independent sample, se ...[more]

PMID: 32737332

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Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction.

Publications

Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction.

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