The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials.

ABSTRACT: The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several thousands of dentinal tubules (∼2 μm in diameter). Although the cytotoxic response of the dental pulp to biomaterials has been extensively studied, there is a shortage of in vitro model systems that mimic the dentin-pulp interface and enable an improved understanding of the morphologic, metabolic and functional influence of biomaterials on live dental pulp cells. To address this shortage, here we developed an organ-on-a-chip model system which integrates cells cultured directly on a dentin wall within a microfluidic device that replicates some of t

SUBMITTER: Franca CM 

PROVIDER: S-EPMC7395925 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature