Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice.
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ABSTRACT:
SUBMITTER: Xu B
PROVIDER: S-EPMC7396510 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice.
Xu Bing B Liu Su-Su SS Wei Jin J Jiao Zi-Yin ZY Mo Cheng C Lv Cheng-Mei CM Huang Ai-Lan AL Chen Qi-Bo QB Ma Li L Guan Xue-Hai XH
Frontiers in neuroscience 20200722
Poor postoperative pain (POP) control increases perioperative morbidity, prolongs hospitalization days, and causes chronic pain. However, the specific mechanism(s) underlying POP is unclear and the identification of optimal perioperative treatment remains elusive. Akt and mammalian target of rapamycin (mTOR) are expressed in the spinal cord, dorsal root ganglion, and sensory axons. In this study, we explored the role of Akt and mTOR in pain-related behaviors induced by plantar incision in mice. ...[more]
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