Ontology highlight
ABSTRACT:
SUBMITTER: Laursen NS
PROVIDER: S-EPMC7396675 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Laursen Nick S NS Pedersen Dennis V DV Gytz Heidi H Zarantonello Alessandra A Bernth Jensen Jens Magnus JM Hansen Annette G AG Thiel Steffen S Andersen Gregers R GR
Frontiers in immunology 20200717
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and <i>in vitro</i> characterization of C1qNb75, a single domain antibody (nanobody) specific for C1q, the pattern recognition molecule of the classical pathway. C1qNb75 binds to the globular head modules of human C1q with sub-nanomolar affinity and impedes classical pa ...[more]