Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.

ABSTRACT:

Background

Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain metabolism. Among neurodegenerative disorders, people living with human immunodeficiency virus (HIV) and Alzheimer's disease (AD) are particularly vulnerable to metabolic disturbances, but the mechanistic connections of inflammation, neurodegeneration and bioenergetic deficits in the central nervous system (CNS) are poorly defined. The particularly interesting new cysteine histidine-rich-protein (PINCH) is nearly undetectable in healthy mature neurons, but is robustly expressed in tauopathy-associated neurodegenerative diseases including HIV infection and AD. Although robust PINCH expression has been reported in neurons in the brains of patients with HIV and AD, the m

SUBMITTER: Natarajaseenivasan K 

PROVIDER: S-EPMC7397656 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature