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Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.

ABSTRACT: Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral resources. The mechanisms that import Kyn into the nervous system are poorly understood. Here, we provide genetic, anatomical, biochemical, and behavioral evidence showing that in C. elegans an ortholog of the human LAT1 transporter, AAT-1, imports Kyn into sites of KynA production.

SUBMITTER: Lin L

PROVIDER: S-EPMC7397858 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Neural production of kynurenic acid in <i>Caenorhabditis elegans</i> requires the AAT-1 transporter.

Lin Lin L Lemieux George A GA Enogieru Osatohanmwen Jessica OJ Giacomini Kathleen M KM Ashrafi Kaveh K

Genes & development 20200716 15-16

Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral resources. The mechanisms that import Kyn into the nervous system are poorly understood ...[more]

PMID: 32675325

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