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Marburg virus disease: A summary for clinicians.
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ABSTRACT: Objectives
This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation.Methods
A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods that were used is summarized in a companion methods paper.Results
The study identified six treatments and four vaccine platforms that have demonstrated, through their efficacy in NHPs, potential benefit for treating or preventing infection in humans.Conclusion
Succinct summaries of Marburg countermeasures are provided to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. Links to other authoritative sources of information are also provided.
SUBMITTER: Kortepeter MG
PROVIDER: S-EPMC7397931 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Marburg virus disease: A summary for clinicians.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20200803
<h4>Objectives</h4>This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation.<h4>Methods</h4>A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate dat ...[more]