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Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight.

ABSTRACT: Background:Controversy exists on the relationship between iron metabolism and cardiometabolic risk. The aim of this study was to determine if there is a link between dysmetabolic iron and cardiometabolic markers in subjects with excess body weight. Methods:Cross-sectional study with fifty participants presenting overweight or obesity and at least another metabolic syndrome factor. Determinations: anthropometry, body composition, blood pressure, lipids, glucose, insulin, leptin, areas under the curve (AUC) for glucose and insulin after an oral glucose tolerance test, hs-C reactive protein (hs-CRP), blood count, ferritin, transferrin, transferrin saturation (TSAT), soluble transferrin receptor (sTfR). Gender-adjusted linear correlations and two independent samples t tests were used. Results:Ferritin was positively correlated with insulin-AUC (r = 0.547, p = 0.008) and TSAT was negatively correlated with waist-hip ratio (r = - 0.385, p = 0.008), insulin (r = - 0.551, p < 0.001), and insulin resistance (HOMA-IR, r = - 0.586, p < 0.001). Subjects with TSAT ? 20% had higher insulin (p = 0.012) and HOMA-IR (p = 0.003) compared to those with TSAT > 20%. In conclusion, the observed results suggest that iron transport and storage are altered in subjects with overweight/obesity, at the same time that they exhibit the characteristic features of insulin resistance. Nevertheless, this occurs without iron overload or deficiency. These results should be validated in wider cohorts since they suggest that iron transport and storage should be assessed when performing the clinical evaluation of subjects with excess body weight.

SUBMITTER: Vaquero MP

PROVIDER: S-EPMC7397981 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight.

Vaquero M Pilar MP Martínez-Maqueda Daniel D Gallego-Narbón Angélica A Zapatera Belén B Pérez-Jiménez Jara J

PeerJ 20200731

<h4>Background</h4>Controversy exists on the relationship between iron metabolism and cardiometabolic risk. The aim of this study was to determine if there is a link between dysmetabolic iron and cardiometabolic markers in subjects with excess body weight.<h4>Methods</h4>Cross-sectional study with fifty participants presenting overweight or obesity and at least another metabolic syndrome factor. Determinations: anthropometry, body composition, blood pressure, lipids, glucose, insulin, leptin, ar ...[more]

PMID: 32821534

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Dataset Information

Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight.

Publications

Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight.

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