Mechanosensing through YAP controls T cell activation and metabolism.
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ABSTRACT:
SUBMITTER: Meng KP
PROVIDER: S-EPMC7398163 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Mechanosensing through YAP controls T cell activation and metabolism.
Meng Kevin P KP Majedi Fatemeh S FS Thauland Timothy J TJ Butte Manish J MJ
The Journal of experimental medicine 20200801 8
Upon immunogenic challenge, lymph nodes become mechanically stiff as immune cells activate and proliferate within their encapsulated environments, and with resolution, they reestablish a soft baseline state. Here we show that sensing these mechanical changes in the microenvironment requires the mechanosensor YAP. YAP is induced upon activation and suppresses metabolic reprogramming of effector T cells. Unlike in other cell types in which YAP promotes proliferation, YAP in T cells suppresses prol ...[more]
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