Ontology highlight
ABSTRACT:
SUBMITTER: Yamagata K
PROVIDER: S-EPMC7398324 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Inflammation and regeneration 20200803
The super-enhancer (SE) is a cluster of enhancers involved in cell differentiation via enhanced gene expression that determines cell identity. Meanwhile, genome-wide association studies (GWASs) have reported the presence of gene clusters containing single nucleotide polymorphisms (SNPs) susceptible to various diseases. According to cell types, these disease-susceptible SNPs are frequently detected in activated SE domains. However, the roles of SEs in the pathogenesis of various diseases remain u ...[more]