Heterogeneity in Fear Processing across and within Anxiety, Eating, and Compulsive Disorders.

ABSTRACT:

Background

To assess within and across diagnosis variability we examined fear processing in healthy controls (HC) and three diagnostic groups that share symptoms of pathological anxiety: obsessive compulsive disorder (OCD); social anxiety disorder (SAD), and anorexia nervosa (AN).

Methods

Unmedicated adults (N=166) participated in a paradigm assessing associative fear acquisition, extinction, extinction recall, and fear renewal. Data were analyzed from two perspectives: comparison of each disorder to HC and exploratory latent class analysis (LCA) of the combined data.

Results

The diagnosis-based analyses indicated significantly increased fear renewal in OCD and trends toward decreased extinction recall in OCD and increased renewal in SAD. The LCA indicated four Respon

SUBMITTER: Fyer AJ 

PROVIDER: S-EPMC7398449 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature