Increased HOXC6 mRNA expression is a novel biomarker of gastric cancer.
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ABSTRACT:
SUBMITTER: Jung J
PROVIDER: S-EPMC7398522 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Increased HOXC6 mRNA expression is a novel biomarker of gastric cancer.
Jung Jiyoon J Jeong Sanghoon S Jeong Hoiseon H Oh Hwa Eun HE Choi Jung-Woo JW Lee Eung Seok ES Kim Young-Sik YS Kwak Yoonjin Y Kim Woo Ho WH Lee Ju-Han JH
PloS one 20200803 8
In this study, we aimed to investigate the molecular biomarkers that are pivotal for the development and progression of gastric cancer (GC). We analyzed clinical specimens using RNA sequencing to identify the target genes. We found that the expression of HOXC6 mRNA was upregulated with the progression of cancer, which was validated by quantitative real time PCR and RNA in-situ hybridization. To compare the protein expression of HOXC6, we evaluated GC and normal gastric tissue samples using weste ...[more]
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