Heritability of territory of ruptured and unruptured intracranial aneurysms in families.

ABSTRACT:

Background

A previous study suggested that intracranial aneurysms are more likely to occur in the same arterial territory within families. We aimed to replicate this analysis in independent families and in a sample limited to intracranial aneurysms that ruptured.

Methods

Among families with ≥2 first-degree relatives with intracranial aneurysms, we randomly matched index families to comparison families, and compared concordance in intracranial aneurysm territory between index and comparison families using a conditional logistic events/trials model. We analyzed three European cohorts separately, and pooled the results with those of the Familial Intracranial Aneurysm study by performing an inverse variance fixed effects meta-analysis. The main analysis included both unruptured

SUBMITTER: van Kammen MS 

PROVIDER: S-EPMC7398535 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature