β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans.

ABSTRACT:

Background

Plasma cholesterol is one of the strongest risk factors associated with the development of atherosclerotic cardiovascular disease (ASCVD) and myocardial infarction. Human studies suggest that elevated plasma β-carotene is associated with reductions in circulating cholesterol and the risk of myocardial infarction. The molecular mechanisms underlying these observations are unknown.

Objective

The objective of this study was to determine the impact of dietary β-carotene and the activity of β-carotene oxygenase 1 (BCO1), which is the enzyme responsible for the conversion of β-carotene to vitamin A, on circulating cholesterol concentration.

Methods

In our preclinical study, we compared the effects of a 10-d intervention with a diet containing 50 mg/kg of β-carote

SUBMITTER: Amengual J 

PROVIDER: S-EPMC7398780 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature