Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature.
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ABSTRACT:
SUBMITTER: Palli R
PROVIDER: S-EPMC7398916 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature.
Palli Rohith R Seaton Kelly E KE Piepenbrink Michael S MS Hural John J Goepfert Paul A PA Laher Fatima F Buchbinder Susan P SP Churchyard Gavin G Gray Glenda E GE Robinson Harriet L HL Huang Yunda Y Janes Holly H Kobie James J JJ Keefer Michael C MC Tomaras Georgia D GD Thakar Juilee J
Scientific reports 20200803 1
Efficacious HIV-1 vaccination requires elicitation of long-lived antibody responses. However, our understanding of how different vaccine types elicit durable antibody responses is lacking. To assess the impact of vaccine type on antibody responses, we measured IgG isotypes against four consensus HIV antigens from 2 weeks to 10 years post HIV-1 vaccination and used mixed effects models to estimate half-life of responses in four human clinical trials. Compared to protein-boosted regimens, half-liv ...[more]
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